中文名替诺福韦艾拉酚胺富马酸盐
英文名TenofovirAlafenamide fumarate
别名替诺福韦艾拉芬胺
富马酸磷丙替诺福韦
替诺福韦艾拉酚胺富马酸
替诺福韦艾拉芬胺半富马酸
替诺福韦艾拉酚胺富马酸盐
替诺福韦艾拉酚胺富马酸半盐
替诺福韦-富马酸阿芬烯胺[ USAN ]
(S)-丙胺酸异丙酯2-{(S)-[((R)-1-(6-氨基-9H-嘌呤-9-基)-1-甲基乙氧基]甲基}-苯氧基磷酰基半反丁烯二酸盐
英文别名Anti-HIV
GS-7340(hemifumarate)
Tenofovir Alafenamide fumarate
Tenofovir levamide amine fumarate
GS7340(Tenofovir Alafenamide Fumarate)
TENOFOVIR ALAFENAMIDE HEMIFUMARATE (GS-7340 HEMIFUMARATE)
CAS1392275-56-7
EINECS805-448-8化学式C25H33N6O9P
分子量592.55溶解度DMSO存储条件Keep in dark place,Sealed in dry,RoomTemperature体外研究Tenofovir alafenamide hemifumarate (GS-7340hemifumarate) antiviral activities are similar across all celltypes, ranging from 5 to 7 nM, while the CC 50 varies from 4.7 to42 μM for MT-4 and MT-2 cells, respectively. The antiviral activityof TAF is evaluated against a panel of HIV-1 and HIV-2 isolates,including HIV-1 group M subtypes A to G, as well as group N and Oisolates. Overall, for the 29 primary HIV-1 isolates tested inPBMCs, TAF EC 50 s range from 0.1 to 12 nM, with a mean EC 50 of3.5 nM compared to a mean EC 50 of 11.8 nM for AZT, which is usedas an internal control. For the HIV-2 isolates, the mean EC 50 sare 1.8 nM for TAF and 6.4 nM for AZT.体内研究Tenofovir alafenamidehemifumarate (GS-7340 hemifumarate) is an amidate prodrug ofTenofovir with good oral bioavailability and increases plasmastability compared to Tenofovir disoproxil fumarate (TDF) .
